A-+Why+are+headache+tablets+buffered?

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 05/01/11
 = Why are headache tablets buffered? =   No one likes getting a headache, so it's good that our pharmacies provide an abundance of headache tablets to choose from. With all the possibilities, it can be a little overwhelming. So, for today's headache cure, let's choose Aspirin.

 **Some facts about aspirin:**  -is the “best researched drug in the world”  -is a common headache, muscle ache and joint ache reliever   -is also known as acetylsalicylic acid with the chemical formula C   9   H   8   O   4   -in ancient roman times, they used willow bark for fighting fevers because the leaves and bark of willow trees contain salicin which is a similar compound to acetylsalicylic acid  -it is so acidic that it can cause heartburn, irritation in the stomach and duodenum and unpleasant side effects like leaking in the blood vessels lining the stomach or duodenum and stomach ulcers   **How does plain aspirin work?**  When you are in pain, a message is sent to the brain by the chemical prostaglandin produced by the enzyme called cylooxygenase-2. This chemical also causes inflammation or swelling in the injured area by releasing fluids. Aspirin prevents the cylooxygenase-2 from producing the prostaglandin and most of the pain signals don't reach the brain which results in less pain being felt. The swelling would also minimize because of the lack of prostaglandin production.  And, to prevent the risk of those unpleasant side effects, we use a buffer.  **What is a buffer? Good question.**  -buffers are any intermediate or intervening shield reducing the interaction between two chemicals.

 In buffered aspirin, you can find a combination of the aspirin and an antacid (ex: calcium carbonate, aluminium hydroxide, or magnesium oxide) which have the ability to reduce heartburn or stomach irritation normally caused by plain aspirin. Buffered tablets also help to quicken the absorption and dissolution of aspirin.

<span style="font-family: Tahoma,sans-serif;"> **How does buffered aspirin work?** <span style="font-family: Tahoma,sans-serif;">  The inactive substance that coats the aspirin neutralizes the acid in the stomach (since it can withstand it's acidity). Also, buffered tablets can use a // layered tablet system //  which help separate the aspirin's opposition with the tablet's buffer. T  he buffer's solubility increases the pH around and in the tablet and the higher pH increases aspirin's solubility which later decreases the acidity of the aspirin.

<span style="font-family: Tahoma,sans-serif;"> **So why are headache tablets buffered?** <span style="font-family: Segoe UI,sans-serif;"> <span style="font-family: Tahoma,sans-serif;">- to counter the acid of the aspirin which leads to a headache-free day without an y side effects.

<span style="font-family: Segoe UI,sans-serif;"> [|How to Use Aspirin in Unusual Ways]

__<span style="font-family: Tahoma,Geneva,sans-serif;">Works Cited List __ <span style="font-family: Tahoma,Geneva,sans-serif;">1.) Balse. Peck, C. M. G. E.. (1992). The development of a unique buffered matrix aspirin tablet., . , Retrieved from Http://journals2. Scholarsportal. Info. Ezproxy. Library. Yorku. Ca/tmp/1950356362105239179. Pdf.

<span style="font-family: Tahoma,Geneva,sans-serif;">2.) Kelly, J. P.. (1996). Risk of aspirin-associated major upper-gastrointestinal bleeding with ecentric-coated or buffered product., 348. , Retrieved from Http://journals2. Scholarsportal. Info. Ezproxy. Library. Yorku. Ca/tmp/8628382551352237739. Pdf.

<span style="font-family: Tahoma,Geneva,sans-serif;">3.) Jost. Kuhn. Rogallak. Theiss. Lucker., V. I. K. U. Pw.. (1992). Gastric potential difference measurement as a quantification of gastrointestinal tolerability comparing a buffered acetylsalicylic-acid formulation versus plain acetylsalicylic-acid., 21-1. 5, Retrieved from Http://apps. Isiknowledge. Com. Ezproxy. Library. Yorku. Ca/full_record. Do? Product=wos&search_mode=generalsearch&qid=6&sid=1cbk3bfladbccibg572&page=1&doc=5&cacheurlfromrightclick=no.

<span style="font-family: Tahoma,Geneva,sans-serif;">4.) Fynn, C.. . The benefits and dangers of aspirin. Retrieved from Http://www. Helium. Com/items/2042823-the-benefits-and-dangers-of-aspirin.

<span style="font-family: Tahoma,Geneva,sans-serif;">5.) Hari. Why is aspirin buffered?. Retrieved from Http://www. Knowswhy. Com/why-is-aspirin-buffered/. <span style="font-family: Tahoma,Geneva,sans-serif;">What is aspirin. Retrieved from Http://www. Aspirin-foundation. Com/what/index. Htmdation. Com/what/chemistry. Html.

<span style="font-family: Tahoma,Geneva,sans-serif;">6.) Aspirin facts. Retrieved from Http://www. Aspirinforpain. Ca/aspirinfacts/index. Asp.

<span style="font-family: Tahoma,Geneva,sans-serif;">7.) Ehow contributer. How does aspirin work in the body?. Retrieved from Http://www. Ehow. Com/how-does_4564317_aspirin-work-body. Html.